20. May 2021

The Problem

inferences we can draw from research syntheses
depend on the decisions in the research process
(Ioannidis, 2016)
e.g. “garbage in garbage out”
(Egger et al., 2001)



degrees of freedom, e.g. in
- literature search
- eligibility criteria
- strategy for data synthesis



transparency allow for critical evaluation & enhance reproducibility
(Wilson, 2019)

The Problem

Open Science Practices help to make research transparent and reproducible
(Page et al., 2021)



preregistration makes research syntheses as a process transparent
(Atkinson et al., 2015; Stewart et al., 2012)



preregistration of research syntheses is not standard procedure yet (outside of health)
(Ioannidis, 2016; Møller et al., 2018)

Existing solutions?

important frameworks

PROSPERO
(Booth et al., 2012)

PRISMA-P
(Moher et al., 2015)

MARS
(Appelbaum et al., 2018)

Existing solutions?

important frameworks

PROSPERO
(Booth et al., 2012)

PRISMA-P
(Moher et al., 2015)

MARS
(Appelbaum et al., 2018)



discipline-specific frameworks


“Preregistration is hard”
e.g. including power analysis, coding manual, data analysis strategy (Nosek et al., 2019)

Existing solutions?

important frameworks






If we want culture change, we need to “make it easy”
(Nosek, 2019)

Our Context


TüDiLB
www.tuedilb-tuebingen.de


Joint project of
University of Tübingen and
Leibniz-Institut für Wissensmedien (IWM)

Research group “Transformation & Translation”

research syntheses on the topic of digitization

in teaching and teacher education

Our Aims

• utilize existing frameworks and standards

• make them accessible & applicable
- for meta-analyses and systematic reviews
- for all disciplines

• enable seamless integration of data analyses, files, figures, text, …

• ensure compatibility with markup languages


produce standalone HTML/PDF

preregRS

R package

preregRS = R Markdown template (install via R-package)

  • provides structure: synthesized
    PROSPERO, PRISMA-P and MARS

preregRS

R package

preregRS = R Markdown template (install via R-package)

  • provides structure: synthesized
    PROSPERO, PRISMA-P and MARS

  • guides with additional information

preregRS

R package

preregRS = R Markdown template (install via R-package)

  • provides structure: synthesized
    PROSPERO, PRISMA-P and MARS

  • guides with additional information

  • fill out like a form: provides placeholders

preregRS

R package

preregRS = R Markdown template (install via R-package)

  • provides structure: synthesized
    PROSPERO, PRISMA-P and MARS

  • guides with additional information

  • fill out like a form: provides placeholders

  • R Markdown enables us to…

include R code and its output
encode files (e.g. separate coding system)
include figures, iframes, latex, …
include interactive content (e.g. plotly)

preregRS

R package

preregRS = R Markdown template (install via R-package)

  • provides structure: synthesized
    PROSPERO, PRISMA-P and MARS

  • guides with additional information

  • fill out like a form: provides placeholders

  • R Markdown enables us to…

include R code and its output
encode files (e.g. separate coding system)
include figures, iframes, latex, …
include interactive content (e.g. plotly)


compile to standalone file

Demo

Demo

check out…

Further developments

  • Increase usability & accessibility outside of R
    e.g. JBI SUMARI

Appelbaum, M., Cooper, H., Kline, R. B., Mayo-Wilson, E., Nezu, A. M., & Rao, S. M. (2018). Journal article reporting standards for quantitative research in psychology: The APA Publications and Communications Board task force report. American Psychologist, 73(1), 3–25. https://doi.org/10.1037/amp0000191

Atkinson, K. M., Koenka, A. C., Sanchez, C. E., Moshontz, H., & Cooper, H. (2015). Reporting standards for literature searches and report inclusion criteria: Making research syntheses more transparent and easy to replicate: Reporting Standards for Literature Searches. Research Synthesis Methods, 6(1), 87–95. https://doi.org/10.1002/jrsm.1127

Booth, A., Clarke, M., Dooley, G., Ghersi, D., Moher, D., Petticrew, M., & Stewart, L. (2012). The nuts and bolts of PROSPERO: An international prospective register of systematic reviews. Systematic Reviews, 1(1), 2. https://doi.org/10.1186/2046-4053-1-2

Egger, M., Smith, G. D., & Sterne, J. A. C. (2001). Uses and abuses of meta-analysis. Clinical Medicine, 1(6), 478–484. https://doi.org/10.7861/clinmedicine.1-6-478

Ioannidis, J. P. A. (2016). The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses. The Milbank Quarterly, 94(3), 485–514. https://doi.org/10.1111/1468-0009.12210

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., & Stewart, L. A. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), 1. https://doi.org/10.1186/2046-4053-4-1

Møller, M. H., Ioannidis, J. P. A., & Darmon, M. (2018). Are systematic reviews and meta-analyses still useful research? We are not sure. Intensive Care Medicine, 44(4), 518–520. https://doi.org/10.1007/s00134-017-5039-y

Nosek, B. A. (2019). Culture change toward more open, rigorous, and reproducible research.

Nosek, B. A., Beck, E. D., Campbell, L., Flake, J. K., Hardwicke, T. E., Mellor, D. T., van ’t Veer, A. E., & Vazire, S. (2019). Preregistration Is Hard, And Worthwhile. Trends in Cognitive Sciences, 23(10), 815–818. https://doi.org/10.1016/j.tics.2019.07.009

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, n71. https://doi.org/10.1136/bmj.n71

Stewart, L., Moher, D., & Shekelle, P. (2012). Why prospective registration of systematic reviews makes sense. Systematic Reviews, 1(1), 7. https://doi.org/10.1186/2046-4053-1-7

Wilson, D. B. (2019). Systematic Coding for Research Synthesis. In H. M. Cooper, L. V. Hedges, & J. C. Valentine (Eds.), Handbook of research synthesis and meta-analysis (3rd edition, pp. 153–172). Russell Sage Foundation.